Living with depression that won’t lift can leave you feeling drained, hopeless, and alone. You deserve to be heard, understood, and cared for. At Luminate, we offer Esketamine (Spravato), an FDA-approved nasal spray for adults with treatment-resistant depression, in a calm, supervised setting with personalized care at every step.
Maybe you’ve lost count of the medications you’ve tried. Maybe each new prescription began with hope and ended with the same heavy feeling, and somewhere along the way you started to wonder if the problem was you. It isn’t. Depression can be stubborn, and needing a different kind of help says nothing about your strength.
If you’re curious about Esketamine but unsure, that’s completely normal. At your first visit, we listen to your story, review the treatments you’ve already tried, and go over your medical history to see whether Spravato is a safe and appropriate option for you. There’s no pressure to decide anything, and we’ll answer every question honestly.

Spravato has been approved by the FDA for adults with depression that hasn't gotten better after at least two antidepressants. It may be used alone or alongside oral antidepressants. We’ll help you decide if it fits.

You take the Esketamine nasal spray yourself in our office, with our team nearby, then rest while we monitor you for at least two hours. Most people begin with two sessions a week for four weeks, then move to weekly or every-other-week visits.

Some people feel dizzy, nauseous, sleepy, or disconnected for a few hours after a dose. Spravato can also raise blood pressure temporarily, so we check it before and after each session. Please don’t drive until the next day after a restful sleep.
If your search for relief led you to ketamine, you may have found a lot of conflicting information. Here is the difference: Esketamine is a closely related form of ketamine, and Spravato is the FDA-approved esketamine nasal spray for treatment-resistant depression. The FDA has not authorized other ketamine formulations for treating depression. We provide Spravato treatment services in Cranford, NJ, in a certified setting because it can only be given under supervision and can never be taken home. We’ll guide you through each step so you feel safe and informed, never rushed.
Whether you have questions, want help checking your insurance, or are ready to book, we’re here for you. We accept most major insurance and are open evenings and weekends.
Every journey with depression is different. These are words from patients who shared their experience with us, in their own voice and with their permission.
"The team was incredibly professional from start to finish. They understood exactly what we needed and delivered outstanding results. Highly recommended!"